Mebeverine, Mebeverine for IBS or Colofac in IBSMebeverine for IBS , treatment of gastrointestinal disorders that cause smooth muscle spasm.
Other names: Colofac for IBS
Cautions: Pregnancy, Breast Feeding, Paralytic Ileus.
Contraindications: Avoid in Pregnancy, known allergy to the drug
Availability: Tablets or Liquid preparations
Dose: Adult and Child (over 10 years) Mebeverine 135mg three times a day 20mins after food.
Adverse effects: No serious adverse effects are known, although allergy could occur as with any drug. Its other name is Colofac. Colofac in Irritable Bowel Syndrome works as an antispasmodic drug, a drug that reduces bowel spasm.
The Doctors View
I've got to say I am not a great fan of this drug. Whilst it can help some sufferers, I have found the majority of sufferers that have tried it prior to seeing me, with little improvement. When you look at the evidence, the drug is tolerated well. However, definite improvement in IBS is debatable. References:1) A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome. Darvish-Damavandi M, Nikfar S, Abdollahi M. World J Gastroenterol. 2010 Feb 7;16(5):547-53. Review.
2) Mebeverine alters small bowel motility in irritable bowel syndrome. Evans PR, Bak YT, Kellow JE. Aliment Pharmacol Ther. 1996 Oct;10(5):787-93.
3) A double-blind crossover comparison study of the safety and efficacy of mebeverine with mebeverine sustained release in the treatment of irritable bowel syndrome.
Van Outryve M, Mayeur S, Meeus MA, Rosillon D, Hendrickx B, Ceuppens M.
J Clin Pharm Ther. 1995 Oct;20(5):277-82.
The IBS Sufferers View:
We would love to hear your thoughts and experiences with this drug. Have you found benefit? Have they caused you any problems? Have they been ineffective? Write your review now and we will publish it for others to benefit from! Write Your Review
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